Poly(2?alkyl?2?oxazoline)?Heparin Hydrogels—Expanding the Physicochemical Parameter Space of Biohybrid Materials

نویسندگان

چکیده

Poly(ethylene glycol) (PEG)-glycosaminoglycan (GAG) hydrogel networks are established as very versatile biomaterials. Herein, the synthetic gel component of biohybrid materials is systematically varied by combining different poly(2-alkyl-2-oxazolines) (POx) with heparin applying a Michael-type addition crosslinking scheme: POx gradated hydrophilicity and temperature-responsiveness provides polymer distinctly stiffness swelling. Adjusting mechanical properties GAG concentration gels to similar values allows for modulating release GAG-binding growth factors (VEGF165 PDGF-BB) choice its temperature-dependent conformation. Adsorption fibronectin, fibroblasts, bacterial adhesion scale hydrophobicity gel-incorporated POx. In vitro hemocompatibility tests freshly drawn human whole blood show advantages POx-based compared PEG-based reference materials. Biohybrid hydrogels can therefore enable biomedical technologies requiring GAG-based customized switchable physicochemical characteristics.

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ژورنال

عنوان ژورنال: Advanced Healthcare Materials

سال: 2021

ISSN: ['2192-2640', '2192-2659']

DOI: https://doi.org/10.1002/adhm.202101327